# Package vsn

## Detailed Description

Title:Variance stabilization and calibration for microarray data Description:The package implements a robust variant of the maximum-likelihood estimator for the stochastic model of microarray data described in the references. The model incorporates data calibration (aka normalization), a model for the dependence of the variance on the mean intensity, and a variance stabilizing data transformation. Differences between transformed intensities are analogous to "normalized log-ratios". However, in contrast to the latter, their variance is independent of the mean, and they are usually more sensitive and specific in detecting differential transcription.
Author:Wolfgang Huber <huber@ebi.ac.uk>, contributions from A. von Heydebreck <heydebre@molgen.mpg.de>, Markus Ruschhaupt <m.ruschhaupt@dkfz-heidelberg.de>, D. Kostka <dennis.kostka@molgen.mpg.de> Maintainer:Wolfgang Huber <huber@ebi.ac.uk> Version:1.8.0 Built:R 2.2.1; i486-pc-linux-gnu; 2006-03-04 19:53:21; unix Date:18 Sep 2005 Depends:R (>= 2.0.0), Biobase (>= 1.4.14) License:LGPL Packaged:Mon Oct 17 00:04:26 2005; biocbuild Suggests:affy, affydata, marray, multtest, limma, hgu95av2cdf URL:http://www.r-project.org, http://www.ebi.ac.uk/huber

kidney

Intensity data for 1 cDNA slide with two adjacent tissue samples from a nephrectomy (kidney)

**Last ouput from kidney(). For all plots see PDF file.**

PDF output with all plots

Example code and log output is in the "Files" section, please see: vsn/kidney/example.log

meanSdPlot

Plot row standard deviations versus row means

**Last ouput from meanSdPlot(). For all plots see PDF file.**

PDF output with all plots

Example code and log output is in the "Files" section, please see: vsn/meanSdPlot/example.log

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